If you arn't familiar with Super Mega Comics, it's MS Paint slosh done all in yellow and black. This is one of my all time favorite comics, webcomic, paper or otherwise. The writing is done on a strictly anti-humor basis and most strips are devoid of traditional punchlines and have absurdity in their place. This is a formula which has been done before, but as webcomics go, Super Mega Comics did it best.
Go check em out. Here is the latest strip as a sample.